
Boutique hotel vacation rentals in Upstate South Carolina
Find and book unique boutique hotels on Airbnb
Top-rated boutique hotels in Upstate South Carolina
Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.
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Popular amenities for Upstate South Carolina boutique hotels
Family-friendly boutique hotels

Hotel room in Asheville
4.73 out of 5 average rating, 77 reviewsBrookstone Lodge an Choice Ascend Collection Hotel
Andi and TomRating, 5 stars3 weeks ago
Great place to stay for the night! Nice room, very clean and friendly staff!

Hotel room in Asheville
4.6 out of 5 average rating, 93 reviewsBrookstone Lodge Asheville Biltmore Village Area
MichelleRating, 5 stars10 months ago
I didn’t talk to Paul while I was there. This is a hotel that is right by the interstate but I didn’t hear the noise in my room. It was nice and clean. Continental breakfast is included. 5 minute drive to Biltmore. Great value!

Hotel room in Asheville
4.48 out of 5 average rating, 206 reviewsBrookstone Lodge Biltmore Village Area
AprilRating, 5 stars1 month ago
Very clean and comfortable. A regular Choice hotel with checkin staff. Loved that it had hardwood instead of carpets or drapes, and bed was comfortable. Hotel had a pool and breakfast included. 10 minutes from Biltmore and an excellent price!!

Hotel room in Asheville
4.58 out of 5 average rating, 33 reviewsBrookstone Lodge Hotel Easy Access I-40 Downtown
JessicaRating, 5 stars6 months ago
Our stay at Brookstone Lodge was great - our room was very clean and spacious and had all the listed amenities. The place was also just a few minutes drive to Biltmore, and many restaurants and amenities. We also appreciated Leslie’s great customer service - he went above and beyond to help us deal with an unexpected wedding attire emergency we had. We highly recommend Brookstone Lodge!
Boutique hotels with a patio

Hotel room in Asheville
4.65 out of 5 average rating, 82 reviewsBrookstone Lodge Boutique Hotel Near City Center
DeannaRating, 5 stars4 months ago
We stayed here for our trip to the Biltmore! Perfect location, nine minutes from the estate, twelve minutes from downtown which has amazing food! Would highly recommend Tupelo Honey and Flour for a breakfast sandwich! The location is a hotel! Everything is completely clean and the beds were beyond comfortable. We absolutely want to come back to Asheville and I absolutely would come back to stay! :)

Hotel room in Greer
3.33 out of 5 average rating, 3 reviewsCharming 1 bedroom with private bathroom
SanderRating, 5 stars40 months ago
Great place: so spacious; the community is very nice, flocks of wild ducks and geese outside, big kitchen, super nice host, Akif, with his creative zeal for economics plus Linda and her dog Bella, for on site accommodations.
Superhost

Hotel room in Hendersonville
4.82 out of 5 average rating, 11 reviewsDouble Queen Rm: Near DT Hendo & Flat Rock
NicholeRating, 5 stars19 months ago
this was the perfect spot for our weekend getaway. the place had everything we needed and was so cute!
Guest favourite

Hotel room in Asheville
5 out of 5 average rating, 7 reviewsBiltmore Hideaway Villa
CathyRating, 5 stars10 months ago
Absolutely perfect!! The location is amazing….walkable to shopping and dining. Getting to and from the condo was super easy too . Can’t wait to stay again 😊

Hotel room in Highlands
4.83 out of 5 average rating, 35 reviewsGranite King Room - 1920's Mid Century Lodge
StevenRating, 5 stars1 month ago
Skyline Lodge is a lovely rehabbed motel leaning into the retro vibe. Staff are friendly. Other guests can be loud, especially if your room is near the on-site restaurant, but that's just life.
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