Guesthouse vacation rentals in Southern United States
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouses in Southern United States
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Southern United States guesthouses
Family-friendly guesthouses
Guesthouse in Gold Hill
4.79 out of 5 average rating, 342 reviewsPeaceful Romantic Cabin In Nature With Jacuzzi tub
Guesthouse in Vero Beach
4.9 out of 5 average rating, 313 reviewsCharming, Barn Apartment on Farm, with Animals
Guesthouse in Atlanta
4.87 out of 5 average rating, 283 reviewsComfortable Guesthouse in Candler Park
Guesthouse in Norman
4.94 out of 5 average rating, 102 reviewsGUEST HOUSE 1.5 miles to OU CAMPUS
Guesthouse in Santa Fe
4.89 out of 5 average rating, 109 reviewsCasita de Luxx: King Bed, Pool, Hot Tub, Views
Guesthouse in Biscayne Park
4.94 out of 5 average rating, 452 reviewsCozy and charming cottage
Guesthouse in Summerville
4.98 out of 5 average rating, 649 reviews★Delightful guest house near historic plantations★
Guesthouse in Saxapahaw
4.92 out of 5 average rating, 703 reviewsThe Yurt at Frog Pond Farm
Guesthouses with a patio
Guesthouse in Jacksonville
4.92 out of 5 average rating, 190 reviewsThe Moody Loft (Murray Hill)
Guesthouse in Yellow Springs
4.99 out of 5 average rating, 211 reviewsModern Remodel Steps to YS, Glen, & Antioch
Guesthouse in Cocoa Beach
4.98 out of 5 average rating, 205 reviewsThe Cocoa Boho Rooftop Retreat
Guesthouse in Orlando
4.88 out of 5 average rating, 221 reviewsCouples Oasis *Heated Pool* and Lake View
Guesthouse in Glen Burnie
4.94 out of 5 average rating, 267 reviewsThe Crab House - a Private, Waterfront Guest House
Guesthouse in Watkinsville
4.99 out of 5 average rating, 121 reviewsDowntown guest house with private hot tub & deck
Guesthouse in Clarkesville
5.0 out of 5 average rating, 154 reviewsCozy guest cottage on historic equestrian property
Guesthouse in Harvest
4.94 out of 5 average rating, 201 reviewsCozy Cottage Tiny House Cabin |Private Porch
Guesthouse rentals with a washer and dryer
Guesthouse in Newark
4.94 out of 5 average rating, 296 reviewsCherry Valley
Guesthouse in Round Top
4.98 out of 5 average rating, 192 reviewsThe Horseshoe Cottage
Guesthouse in Atlanta
4.87 out of 5 average rating, 797 reviews❤️️ Independent Guest House & Huge Outdoor Space
Guesthouse in Alpharetta
4.99 out of 5 average rating, 309 reviewsOwl Creek Chapel
Guesthouse in Orlando
4.98 out of 5 average rating, 354 reviewsLakefront Seclusion Modern Guesthouse+Pool+Hot Tub
Guesthouse in Wilmington
4.96 out of 5 average rating, 492 reviewsCrestwood Cottage
Guesthouse in Tuckasegee
4.99 out of 5 average rating, 178 reviewsWolf Lake Escape - lake & mountain retreat
Guesthouse in Indianapolis
4.99 out of 5 average rating, 785 reviewsPrivate and Charming Carriage House Downtown Indy
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