Hotel vacation rentals in South Carolina
Find and book unique hotels on Airbnb
Top-rated hotels in South Carolina
Guests agree: these hotels are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for South Carolina hotels
Family-friendly hotels
Hotel room in Edisto Island
5.0 out of 5 average rating, 12 reviewsWyndham Ocean Ridge - Edisto Island ** 1 Bedroom
Resort in Hilton Head Island
5.0 out of 5 average rating, 4 reviewsOceanfront, Brand new Luxury Suite!!
Resort in Myrtle Beach
2 Bdrm - South Beach Resort - Myrtle Beach, SC
Resort in Myrtle Beach
Myrtle Beach, Ocean Front Apt, July 7- July 14
Hotel room in Charleston
4.67 out of 5 average rating, 285 reviewsCharleston's Most Charming Historic Inn
Resort in Myrtle Beach
5.0 out of 5 average rating, 4 reviews1 bdrm condo, South Beach Resort, Beach Access
Hotel room in Clemson
5.0 out of 5 average rating, 7 reviewsTwo private rooms with bathroom
Hostel in Charleston
4.72 out of 5 average rating, 385 reviewsThe Goldman Room @ The Annex
Hotels with a pool
Pension in Myrtle Beach
4.65 out of 5 average rating, 20 reviewsLaurel Court 210 in Kingston resort, Pools & Beach
Resort in Pawleys Island
4.62 out of 5 average rating, 13 reviewsBubbles Up at Litchfield By The Sea
Hotel in Myrtle Beach
4.82 out of 5 average rating, 11 reviewsOceanfront Blvd.
Hotel in Folly Beach
5.0 out of 5 average rating, 3 reviewsPerfectly perched for sea-gazing
Boutique hotel in North Charleston
4.79 out of 5 average rating, 123 reviewsThe Starlight Motor Inn - King + Pool!
Resort in Myrtle Beach
4.76 out of 5 average rating, 74 reviewsCharming condo in Landmark hotel-Sleeps 4
Resort in Myrtle Beach
5.0 out of 5 average rating, 3 reviewsOF-Paradise/pools/Hottubs/lazyriver&waterpk/20%off
Room in Irmo
5.0 out of 5 average rating, 10 reviewsRelax in beach themed room.
Hotels with a patio
Casa particular in Charleston
New place to stayPura Vida Unit 2- Modern Tiny Apartment Charleston
Casa particular in North Myrtle Beach
New place to stayCozy Oceanfront Condo
Casa particular in Hilton Head Island
New place to stayHeritage Classic 2025 Villa
Room in Spartanburg
4.96 out of 5 average rating, 24 reviewsLovely 1 br/1 private bath.
Nature lodge in Greenville County
4.88 out of 5 average rating, 8 reviewsCabin near Pretty Place!
Hostel in Sunset
4.75 out of 5 average rating, 4 reviews"Bobcat" Room in Wilderness Hostel
Place to stay in Anderson
4.74 out of 5 average rating, 31 reviewsThe Michele Suite
Resort in Myrtle Beach
4.91 out of 5 average rating, 32 reviews2bd 2ba ocean view condo
Destinations to explore
- Aparthotel rentals United States
- Boutique hotel rentals United States
- Hotel rentals United States
- Family-friendly rentals South Carolina
- Tiny house rentals South Carolina
- Fitness-friendly rentals South Carolina
- Beach condo rentals South Carolina
- Rentals with a sauna South Carolina
- Resort rentals South Carolina
- Rentals with a washer and dryer South Carolina
- Kid-friendly rentals South Carolina
- Beach house rentals South Carolina
- Farmstay rentals South Carolina
- Rentals with a firepit South Carolina
- Serviced apartment rentals South Carolina
- Rentals with an accessible height bed South Carolina
- Rentals with an accessible height toilet South Carolina
- Guesthouse rentals South Carolina
- Cabin rentals South Carolina
- Rentals with a home theater South Carolina
- Apartment rentals South Carolina
- Private suite rentals South Carolina
- Smoking-friendly rentals South Carolina
- Rentals with pools South Carolina
- Monthly Rentals South Carolina
- Rentals with breakfast South Carolina
- Rentals with outdoor seating South Carolina
- Rentals with lake access South Carolina
- Waterfront rentals South Carolina
- Hostel rentals South Carolina
- Pet-friendly rentals South Carolina
- Luxury rentals South Carolina
- Wheelchair accessible rentals South Carolina
- Bed and breakfasts South Carolina
- Ski-in/ski-out rentals South Carolina
- Villa rentals South Carolina
- Rentals with a hot tub South Carolina
- Rentals with a fireplace South Carolina
- Lake house rentals South Carolina
- Condo rentals South Carolina
- Boutique hotel rentals South Carolina
- House rentals South Carolina
- Rentals with an EV charger South Carolina
- RV rentals South Carolina
- Townhouse rentals South Carolina
- Cottage rentals South Carolina
- Bungalow rentals South Carolina
- Beachfront rentals South Carolina
- Campsite rentals South Carolina
- Rentals with a patio South Carolina
- Aparthotel rentals South Carolina
- Rentals with a kayak South Carolina
- Rentals with beach access South Carolina
- Loft rentals South Carolina
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom