Boutique hotel vacation rentals in South Carolina

Find and book unique boutique hotels on Airbnb

Top-rated boutique hotels in South Carolina

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

Boutique hotel in North Charleston

4.79 out of 5 average rating, 127 reviews

The Starlight Motor Inn - King + Pool!

The Starlight Motor Inn is a historic mid-century motel in the heart of N. Charleston, SC! Family run since 1961, The Starlight was conceived as an affordable and accessible destination for locals and visitors alike. In 2022 the property was lovingly restored & reimagined as a 51 room oasis conveniently located on Rivers Avenue just minutes from downtown Charleston. The property is complete with a fabulous pool, full service bar The Burgundy Lounge with nightly live entertainment, & event space!

Guest favourite

Boutique hotel in Charleston

4.94 out of 5 average rating, 138 reviews

INDIGO room at Pinckney

Welcome to the INDIGO room. This historic INN boasts 5 charming rooms with exterior access at the heart of the market and stables. Please click our bio photo to view all rooms, rates & reviews. You will enjoy a King bed, private bath, wifi, TV and a Fireplace in cooler months. Complimentary snacks, pastries and beverages. INDIGO is located on the second floor, you will need to climb stairs. We do not offer onsite parking but convenient parking lots are all within 1-2 blocks. $20-30 per night.

Superhost

Boutique hotel in Charleston

4.75 out of 5 average rating, 53 reviews

The Patio Suite

Charming studio English Basement suite located in a fully renovated 1850's antebellum mansion. No detail was overlooked in the renovation of this historic home in Charleston's Cannonborough neighborhood, featuring beautifully restored cypress wall panelling, a custom-kitchenette with high-end finishes, French Baroque inspired-tin ceiling paneling, and exquitie bath finishes including reclaimed 1854 Vermont roofing slate from the house and a polished nickel British high-tank water closet.

Superhost

Boutique hotel in Folly Beach

4.87 out of 5 average rating, 104 reviews

The Brass Lady

This is one sweet room in a beautifully updated beach guest house that sits back from the marsh, is minutes walking to the beach, and 1/2 block from town. The rooms are rented individually and have their private entrance, deck and bath while sharing a kitchen, dining area and hall with 4 other private rooms located in the guest house. Also, there are shared decks towards the front of the property with grills and a lounge area that can be enjoyed. Grab provided beach towels and chairs.

Boutique hotel in Myrtle Beach

3.64 out of 5 average rating, 11 reviews

King Suite

Step into your spacious king suite and experience the epitome of boutique charm. Adorned with contemporary furnishings your king suite boasts a plush king-size bed, ensuring a restful night's sleep for you and your fellow travelers. Indulge in the luxury of your expansive bathroom, featuring modern fixtures, a sleek vanity, and a spacious shower. With plenty of closet space, you'll find ample room to stow away your belongings, keeping your suite tidy and organized throughout your stay.

Guest favourite

Boutique hotel in Sellers

4.92 out of 5 average rating, 13 reviews

Magnolia Manor: Diamond Suite

Stunning first-floor room with a bay window and private en suite bathroom. Located just 10 minutes from I-95, 30 minutes from Florence, and 1 hour from Myrtle Beach, the Magnolia Manor is the perfect escape for a romantic getaway, the independent traveler seeking adventure, or the family looking for a place to rest on a long road trip (additional rooms available to rent). The fee includes access to the dining room, lounge, coffee bar, upper balcony, and partial access to the grounds.

Superhost

Boutique hotel in Sunset

4.3 out of 5 average rating, 10 reviews

"Muskrat" room at Wilderness Retreat Center

The Lakeside Lodge Hostel is part of a retreat center located close to many outdoor activities in the Upstate of South Carolina, close to the North Carolina border. There are waterfalls, hiking trails, lakes, and great State Parks all within 30 minutes. The Hostel offers clean, comfortable rooms. The Lakeside Lodge has a kitchen, living room, and pavilion that guests can access, as well as all the outdoor spaces of the beautiful retreat center, like a large lake and creek.

Boutique hotel in Myrtle Beach

3.78 out of 5 average rating, 40 reviews

Grande Beach Resort Queen Suite

This room is equipped with a 2 queen size beds, tv, free Wi-Fi, microwave, refrigerator & an en suite bathroom. This is a hotel room inside a newly renovated OCEAN FRONT hotel with all ocean view rooms. Centrally located, Grande Beach offers a chance to stay close to all the main attractions. Offering a convenient location with modern comfort and a perfect escape right on the beach. Enjoy the large pools in between fun activities in town or at the beach.

Boutique hotel in Myrtle Beach

3.92 out of 5 average rating, 126 reviews

OCEAN VIEW Aventura on the Ocean Double Room

Walk out of your hotel room onto the sandy beaches. This room is equipped with two queen size beds, tv, mini fridge, microwave, stove top, free wifi & an en suite bathroom. This room is OCEAN FRONT. Centrally located, Aventura on the Ocean offers a chance to stay close to all the main attractions. Offering a convenient location with modern comfort and a perfect ocean front escape. Enjoy the large pool in between fun activities in town or at the beach.

Guest favourite

Boutique hotel in Folly Beach

4.92 out of 5 average rating, 63 reviews

Boutique Hotel Folly Room 4: King Studio

The Studio room has a living area, kitchenette, and King size bed in the same room. There is a full bathroom. This studio room is on the third floor. Dog friendly with a one-time fee of $110 per dog up to 3 nights, and $150 per dog for 4 or more nights. Fee is added once your reservation is confirmed. PLEASE NOTE THE LOCATION OF THIS ROOM IS ON THE 3RD FLOOR AND IS IN THE MIX OF COMMERCIAL CENTER STREET ACTIVITY, YOU WILL HEAR THE NOISE

Superhost

Hotel room in Charleston

4.67 out of 5 average rating, 287 reviews

Charleston's Most Charming Historic Inn

In the heart of Charleston’s charming historic district sits The Elliott House Inn, one of the most beloved historic Charleston properties. Featuring a cozy and quaint guestroom that opens to a delightful Charleston styled courtyard. This room features rich hardwood floors, an armoire, and all in room amenities.