Boutique hotel vacation rentals in South Carolina

Find and book unique boutique hotels on Airbnb

Top-rated boutique hotels in South Carolina

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

Hotel room in North Charleston

4.78 out of 5 average rating, 259 reviews

The Starlight Motor Inn - King + Pool!

The Starlight Motor Inn is a historic mid-century motel in the heart of N. Charleston, SC! Family run since 1961, The Starlight was conceived as an affordable and accessible destination for locals and visitors alike. In 2022 the property was lovingly restored & reimagined as a 51 room oasis conveniently located on Rivers Avenue just minutes from downtown Charleston. The property is complete with a fabulous pool, full service bar The Burgundy Lounge with nightly live entertainment, & event space!

Superhost

Hotel room in Charleston

4.91 out of 5 average rating, 162 reviews

INDIGO room at Pinckney

Welcome to the INDIGO room. This historic INN boasts 5 charming rooms with exterior access at the heart of the market and stables. Please click our bio photo to view all rooms, rates & reviews. You will enjoy a King bed, private bath, wifi, TV and a Fireplace in cooler months. Complimentary snacks, pastries and beverages. INDIGO is located on the second floor, you will need to climb stairs. We do not offer onsite parking but convenient parking lots are all within 1-2 blocks. $20-30 per night.

Hotel room in Charleston

4.76 out of 5 average rating, 54 reviews

The Patio Suite

Charming studio English Basement suite located in a fully renovated 1850's antebellum mansion. No detail was overlooked in the renovation of this historic home in Charleston's Cannonborough neighborhood, featuring beautifully restored cypress wall panelling, a custom-kitchenette with high-end finishes, French Baroque inspired-tin ceiling paneling, and exquitie bath finishes including reclaimed 1854 Vermont roofing slate from the house and a polished nickel British high-tank water closet.

Guest favourite

Hotel room in Folly Beach

4.88 out of 5 average rating, 117 reviews

The Brass Lady

This is one sweet room in a beautifully updated beach guest house that sits back from the marsh, is minutes walking to the beach, and 1/2 block from town. The rooms are rented individually and have their private entrance, deck and bath while sharing a kitchen, dining area and hall with 4 other private rooms located in the guest house. Also, there are shared decks towards the front of the property with grills and a lounge area that can be enjoyed. Grab provided beach towels and chairs.

Superhost

Hotel room in Myrtle Beach

5 out of 5 average rating, 4 reviews

Oceanfront Penthouse-Style Lux Condo w/ Amenities

It's like a country club in the sky! Enjoy a luxurious getaway in this oceanfront penthouse-style condo on the 14th floor of the Maisons Sur Mer building on Shore Dr. on the north end of Myrtle Beach. With views to the NE, E, S, & SW, you can enjoy sunrises + sunsets from your balconies overlooking the white Grand Strand beaches. Country club amenities w/ a gorgeous pool, putting green, fitness facility, tennis courts, dining. Sleeps 6 across 3 beds + 1-2 on couches, w/ 2 full bathrooms.

Guest favourite

Hotel room in Sellers

4.93 out of 5 average rating, 14 reviews

Magnolia Manor: Diamond Suite

Stunning first-floor room with a bay window and private en suite bathroom. Located just 10 minutes from I-95, 30 minutes from Florence, and 1 hour from Myrtle Beach, the Magnolia Manor is the perfect escape for a romantic getaway, the independent traveler seeking adventure, or the family looking for a place to rest on a long road trip (additional rooms available to rent). The fee includes access to the dining room, lounge, coffee bar, upper balcony, and partial access to the grounds.

Guest favourite

Hotel room in Murrells Inlet

4.96 out of 5 average rating, 114 reviews

The Inlet Cottage Guests Suite

You’ll love the stylish decor of this charming place to stay. Decorated with the ‘beach’ vibe. One block from the beautiful Murrells Inlet Marshwalk and Restaurants.This is a totally private area at the back of our home. You will have access to the pool, hot tub and private deck. There is a refrigerator in your room as well as a stocked coffee bar. There are other toiletries available if you forget anything. Bath and pool towels are in the room.

Guest favourite

Hotel room in Folly Beach

4.92 out of 5 average rating, 75 reviews

Boutique Hotel Folly Room 4: King Studio

The Studio room has a living area, kitchenette, and King size bed in the same room. There is a full bathroom. This studio room is on the third floor. Dog friendly with a one-time fee of $110 per dog up to 3 nights, and $150 per dog for 4 or more nights. Fee is added once your reservation is confirmed. PLEASE NOTE THE LOCATION OF THIS ROOM IS ON THE 3RD FLOOR AND IS IN THE MIX OF COMMERCIAL CENTER STREET ACTIVITY, YOU WILL HEAR THE NOISE

Hotel room in Folly Beach

4.76 out of 5 average rating, 17 reviews

Folliday Inn-The Ariston-Room 34, Pet Friendly

Room 34 - The Ariston: 2nd floor guest room w/entry from a covered porch. Queen-sized bed for up to 2 guests. Private bathroom is outfitted w/a tub & shower. Take a dip at the largest pool on Folly Beach. Beach access is 1 block away. Mini fridge, microwave, smart TV, & free WIFI. No smoking. Pet friendly w/ additional $125 + tax fee. Must be 21+. 1 parking pass provided. Pool will be closed from Sept 3 -8, 2024.

Hotel room in Mount Pleasant

5 out of 5 average rating, 5 reviews

Shem Creek Inn, CREEK SIDE KING

Discover your dockside hideaway at the Shem Creek Inn, a hotel built on local traditions and a treat for visitors. Located in Mount Pleasant, SC, you’ll have relaxing accommodations across the harbor from Downtown Charleston. Your room charge will be paid prior to your arrival. The remaining balance of taxes (13%), destination fee ($2.26/night) and resort fee ($10/night) will be charged upon arrival.

Superhost

Hotel room in Charleston

4.69 out of 5 average rating, 307 reviews

Charleston's Most Charming Historic Inn

In the heart of Charleston’s charming historic district sits The Elliott House Inn, one of the most beloved historic Charleston properties. Featuring a cozy and quaint guestroom that opens to a delightful Charleston styled courtyard. This room features rich hardwood floors, an armoire, and all in room amenities.