
Hotel vacation rentals in South San Francisco
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Top-rated hotels in South San Francisco
Guests agree: these hotels are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for South San Francisco hotels
Family-friendly hotels

Club Wyndham Canterbury One-Bedroom Suite
Nice Hotel, everything was clean and comfortable. Unfortunately there is no parking, it's near by and costs 40$ a day. But I think that's pretty common in this area.

Superior King Room with Ensuite Bathroom
What a lovely place to stay! To be honest, we stayed because of the reviews saying it was located in a noisy area full of nightlife! We wanted to be immersed in a vibrant neighborhood and we were not disappointed. So much good energy just steps away. From a giant park with artists and musicians by day to local restaurants and bars with live music by night. So much amazing food! So many wonderful bars. And it really wasn’t loud at night from inside our room. We slept peacefully. The Inn itself was a total delight. Super cute inside with many nice touches such as a wonderfully stocked 24 hr coffee bar and several seating options. We brought back food several times and just enjoyed the common space. The room was adorable, cozy and just perfect for our needs. You cannot beat this location. We walked everywhere within minutes. Close to cable car line so easy to get around if you don’t want to go everywhere on foot. I’d absolutely stay again!

Elegant Union Square hotel room
We were so pleased with our accommodations at Club Donatello. The beds were super comfortable with awesome sheets. It was very quiet, day and night, and the entire room - the entire hotel, actually - was immaculate. Although Covid restrictions meant no coffee was being served on the club level, it was unexpectedly lovely up there with a large wrap-around terrace. Meimei was extremely responsive and helpful. I have already recommended this airbnb to friends and definitely plan to be back.

Standard Quad Room w/Ensuite Bathroom
The best place I’m love it 😍

Studio Suite with Kitchen
Been booking this place for a couple of weeks now for some work in Sunnyvale and it’s great for staying for up to a week because of it’s kitchen. Space is also huge!

Contemporary & Cozy Room - City Center
Clean and high quality rooms. very attentive and pleasant staff

Hotel Pac Hgts 2 Bed Free Car ParkF
This inn was a pretty nice place to stay. Could do a little better on cleanliness but it was still good. Location is great and there was parking so it was a plus.

Standard Queen Room with Shared Bathroom & Kitchen
I've stayed here 4 times and will stay more. That should say enough about the value of location of this AirBnb.
Hotels with a pool

Guild & Pepper bath amenities & courtyard views
Nice place to stay for the value. Easily walkable to SF SOMA and Market Street areas. The front desk is super helpful and friendly. Absolutely recommended if you're looking for a good value place to stay in SF. Note: they do charge a $20/night fee on top of the Airbnb booking and will require a $200 deposit hold on your credit card when you check in. The deposit is refunded when you check out if there are no issues.

Newly Renovated Room No Cleaning Fee Pleasanton!
Enjoyed my stay at Four Points! Front desk was extremely helpful. The outside pool/garden area was well kept and nice to be able to walk out to from the first floor rooms. Will definitely stay here again.

Best Place to Unwind! 2 Spacious Units, Pool
Thank you everything was perfect, we will definitely be going back if in the area.

Cozy - East popular Destination - Free Breakfast
Hyatt House is an extended stay hotel/condo complex that is part of the Hyatt family. The team were extremely helpful. Housekeeping came in every other day - a pleasant surprise! Onsite parking is generous. The front desk team were always ready to help with a smile. Laundry facilities on site were in perfect working order. That's rare at other places. We found the location to be super convenient for going anywhere in the Bay Area and not just on the Mid-Peninsula. We'll be back.

King bedroom in Silicon Valley hotel
I had to stay here for couple of days when I came in to work at my bay area office. It got the job done for me.

Feel the Spacious Studio: Free Breakfast
Comfortable room to sleep for our overnight stay

Relax to our Spacious Room l NO Cleaning fee
Everything about our stay was great other than the check in process. The front desk clerk was extremely friendly and helpful in getting the problem resolved but the reservation was somehow under my maiden name instead of my current name that I actually made the reservation under. I’m not sure where the disconnect was but fortunately they were flexible since the reservation name was not identical to the name on my ID. Other than this our stay was great! The gym was much better than your typical hotel gym, the room was spotless and the location was convenient and safe!
Hotels with a patio

Rock Roulade Cocoon
Perfect stay! So easy and great central area - even brought my dog and so accommodating – just perfect and exactly what I needed. Thank you so much for sharing your home! Kindly, Kalli

Limantour Lodge - Laguna House
The place was a perfect location for a getaway from San Francisco.

Broadmoor Large Studio 245
From the minute, I walked in to check in I knew I had found my home away from home in San Francisco. The atmosphere was joyful and friendly, the staff was so helpful and the lovely senior citizens were charming. They have an included breakfast that is cooked to order and simply delicious. I had to extend my stay due to some weather at my destination, and they were responsive and took care of me immediately. The bed was super comfortable. The linens were soft and clean. And the icing on the cake was the lovely outdoor patio where I could relax after a day of sightseeing. There was even a delicious bottle of red wine in my room when I checked in. My daughter lives just around the corner so I will be visiting San Francisco often and feel comfortable safe and well taken care of at the Broadmoor. I miss you guys already!

5Bd Entire Flat, Central, Close to Castro, Mission
Sri’s place was the perfect spot for a big family visiting SF! The house is spacious rooms are spread out - allowing you to feel like you have a space to retreat to along with several shared spaces where you can be together. Walkable to Duboce Park, public transit and great bars and restaurants. My family thoroughly enjoyed their stay here - we highly recommend this spot!

Broadmoor Studio 347
Great location. Easily walkable to any main attractions. Great host and very responsive/understanding.

San Francisco Suites Studio II on Nob Hill
Had everything we needed for a quick stay and was within walking distance of a lot of attractions !

(Queen Bed) Room
A great place to stay, very close to downtown Redwood City. It gets a little sketchy after dark. The room it’s self was very clean and kept neat but keep in mind it’s a very small space. Overall, a great cozy space while you explore the city.
Quick stats about hotel rentals in South San Francisco
Total rentals
50 properties
Nightly prices starting at
$222 CAD before taxes and fees
Total number of reviews
230 reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
40 properties allow pets
Rentals with a pool
10 properties have a pool
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- Golden Gate Park
- Stanford University
- Washington Square
- Joaquin Miller Park
- Children’S Fairyland
- Muir Woods National Monument
- Oracle Park
- Golden Gate Bridge
- El Granada Beach
- Surfers Beach
- Glen Canyon Park
- Big Basin Redwoods State Park
- Point Reyes National Seashore
- SAP Center
- Mission Dolores Park
- Oakland Zoo
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- Six Flags Discovery Kingdom
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- Pacifica State Beach
- Painted Ladies
- San Francisco Zoo
- Pier 39
- Googleplex