Vacation rentals in Seneca

Find and book unique accommodations on Airbnb

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Popular amenities for Seneca vacation rentals

Stay near Seneca's top sights

Paesano's Italian Restaurant44 locals recommend
Solé Grill and Sushi Bar26 locals recommend
South Cove County Park26 locals recommend
The Tiki Hut Lakeside Grill22 locals recommend
Keowee Brewing Company22 locals recommend
Lake Keowee Marina19 locals recommend

Other great vacation rentals in Seneca

Superhost
Vacation home in Anderson
4.94 out of 5 average rating, 18 reviews

Clemson/Anderson Lake Hartwell

AmyRating, 5 stars1 month ago
Pat was extremely communicative and the home fit our family of 10 perfectly. There are 2 large bedrooms on the main level, one, a King with small private bath and the other, a queen bed with large private bathroom. There were 2 additional full baths on the main level as well. The kitchen was extra large, very well stocked and accommodated our large family! There is an oversized family room with lots of seating and a bar area too! The family room off the kitchen faces the back deck and the lake and I enjoyed lots of time there reading books to my Grand baby. The back deck was oversized and the home literally sits on Lake Hartwell ! The back dock was a nice bonus as was the hot tub! The downstairs does have some steep stairs so I wouldn't advise elderly people sleeping down there. However, you will find a full bathroom, 2 bedrooms and a third bedroom/bonus/flex space with 2 full beds. We loved our family time there celebrating our daughter's wedding! We can't wait to go back!
Guest favourite
Cabin in Highlands
4.97 out of 5 average rating, 77 reviews

Beautiful Highlands Cabin: Fun Game Room, Hot Tub

KellyRating, 5 stars1 month ago
Thank you for letting us stay at your home. It was a great getaway for us and well worth the drive from Ohio! The location was perfect as it was close to hiking locations, great restaurants and fun activities. The game room was a big hit and my kids want to come back again soon! Thank you again for everything!
Guest favourite
Cabin in Sky Valley
4.95 out of 5 average rating, 20 reviews

The Honey Pot- peaceful cabin -fireplace and deck

AnaRating, 5 stars3 months ago
We love visiting sky valley and Jennifer’s place did not disappoint! It was a peaceful paradise nestled in the hills. We all had so much fun! Would book again for sure!
Guest favourite
Home in Easley
4.79 out of 5 average rating, 33 reviews

Jess & Bailey's Easley Escape

JulieRating, 5 stars3 weeks ago
This was my second stay at this lovely home because I liked it so much the first time. As long as my family is in the area and I haven’t moved to the area, I’ll stay again if it’s available!
Guest favourite
Cabin in Fair Play
4.97 out of 5 average rating, 90 reviews

Her Redhead Cabin on Lake Hartwell w/ Private Dock

SeanRating, 5 stars1 month ago
What a amazing place ! My wife and I came for a weekend getaway and were blown away by how accommodating Mimi and Gene were . The place was above and beyond what we expected ! Absolutely adorable place and perfectly equipped with everything you need for a great stay ! Can’t say enough about the place and the hosts ! We booked another stay here within hours of checking in ! We have stayed at a lot of air bnbs and this has to be up there with one of our favorites :)
Superhost
Home in Cashiers
4.89 out of 5 average rating, 90 reviews

10min DWTN Cashiers! 5mn to SilverRun Waterfall

AshleyRating, 5 stars1 month ago
We loved the beautiful view overlooking the mountains—especially from the bedrooms, which all faced the stunning scenery. We do wish the main living areas had been oriented toward the view since we spent more time there, but overall the space fit our family really well. One of the bedrooms had a queen bed, a twin, and bunk beds, which was perfect for our family of five. Comfortable, spacious, and a great setup for a mountain getaway.
Guest favourite
Farm stay in Clayton
4.95 out of 5 average rating, 82 reviews

Mountain house perfect for nature lovers!

AudreyRating, 5 stars6 days ago
Our family loved Pippas place! We spent the time in the more than expansive home celebrating a birthday, using the grill, sitting at the fire pit each night, having evening visits with the sweet donkey we got to feed some carrots, and endless fishing on the property for our son. Very safe for kids.
Guest favourite
Home in Pickens
4.98 out of 5 average rating, 40 reviews

Happy Trails: Jacuzzi, Lookout Tower, Views!

JenniferRating, 5 stars2 weeks ago
We rented the Airbnb for a wedding weekend! The house exceeded our expectations and was a wonderful place for the bridal party to stay! Plenty of space and excellent communication for the host! Would definitely recommend!!

Quick stats about vacation rentals in Seneca

  • Total rentals

    50 properties

  • Nightly prices starting at

    $55 CAD before taxes and fees

  • Total number of reviews

    2.1K reviews

  • Family-friendly rentals

    30 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

Destinations to explore

  1. Airbnb
  2. United States
  3. South Carolina
  4. Oconee County
  5. Seneca