Guesthouse vacation rentals in Charleston County
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Top-rated guesthouses in Charleston County
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Charleston County guesthouses
Family-friendly guesthouses
Guesthouse in North Charleston
4.94 out of 5 average rating, 350 reviewsCozy Park Circle, Charleston Guest House
Guesthouse in Summerville
4.94 out of 5 average rating, 215 reviewsNina's Cottage -Historic Downtown Summerville
Guesthouse in North Charleston
5.0 out of 5 average rating, 113 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in Charleston
4.91 out of 5 average rating, 654 reviewsIsland Oasis—Near Downtown
Guesthouse in Ridgeville
4.82 out of 5 average rating, 215 reviewsPond House Bungalow at Natural Gathering Grounds
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 229 reviewsGreen Garden Studio @greengardenstudio2017
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 100 reviews5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!
Guesthouse in North Charleston
4.86 out of 5 average rating, 446 reviewsPark Circle Jungalow Loft
Guesthouses with a patio
Guesthouse in Charleston
4.96 out of 5 average rating, 132 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Johns Island
4.91 out of 5 average rating, 113 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Charleston
4.98 out of 5 average rating, 128 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Hanahan
4.99 out of 5 average rating, 84 reviewsThe Violet Villa w/ no cleaning fee
Guesthouse in Goose Creek
4.96 out of 5 average rating, 51 reviewsThe Blue Secret
Guesthouse in Charleston
4.94 out of 5 average rating, 82 reviewsSpacious 1 bedroom cottage in Avondale
Guesthouse in Charleston
4.95 out of 5 average rating, 94 reviewsBoHo styled casita in adorable neighborhood...
Guesthouse in Charleston
4.98 out of 5 average rating, 49 reviewsCountry in the City, "The Outback"
Guesthouse rentals with a washer and dryer
Guesthouse in Charleston
4.99 out of 5 average rating, 210 reviewsRedesigned suite! 12min to city, pet-friendly
Guesthouse in Charleston
4.9 out of 5 average rating, 556 reviewsCute, Cozy, Charleston Cottage
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 224 reviewsCozy Apartment in Mount Pleasant
Guesthouse in Charleston
4.98 out of 5 average rating, 246 reviewsDetached Guest Suite
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 260 reviews#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Guesthouse in North Charleston
4.94 out of 5 average rating, 118 reviewsNewly Renovated Studio in Park Circle
Guesthouse in Charleston
4.99 out of 5 average rating, 150 reviewsLarge Guesthouse with Private Dock & Marsh Views
Guesthouse in Charleston
5.0 out of 5 average rating, 222 reviewsJames Island "La Casita" Nestled btw Beach & City
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