Guesthouse vacation rentals in San Diego

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouses in San Diego

Guests agree: these guesthouses are highly rated for location, cleanliness, and more.

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Guest favourite

Guesthouse in San Diego

4.97 out of 5 average rating, 344 reviews

Diamond Villa in the Heart of Pacific Beach

3 blocks to the beach & 2 blocks off main st, newly constructed detached living space w/private entrance & shared yard: spacious 1 bedroom, 1 bath, lg living rm w/an accordion glass door to patio/deck, 2 flat screen TVs w/cable & wifi , leather sofas, gas fireplace, kitchenette, gas grill, propane heater on deck, top level has wet bar, chairs & gas fit pit, bay & ocean peek views from top level, private entrance, outdoor warm shower for after beach rinse, Jacuzzi & wood fire pit in shared yard

Oct. 19 – 26

$233 CAD per night

Guest favourite

Guesthouse in Escondido

4.92 out of 5 average rating, 639 reviews

Hilltop cabin retreat with lake & mountain views

Rustic hilltop cabin overlooking Lake Hodges. Surrounded by open canyons & mountains, you will feel like you're a million miles away from everything as you take in the views from the cabin, deck or the outside shower, swim in the saltwater pool, or relax by the fire bowl. A short walk to lake with boating, fishing & miles of hiking/mountain biking trails. Property offers swimming pool, fire bowl, and shaded arbor. SD Zoo Safari Park, wineries, breweries, & ocean beaches all within easy reach.

Sep. 13 – 20

$244 CAD per night

Guest favourite

Guesthouse in San Diego

4.97 out of 5 average rating, 507 reviews

Central & Serene Secret Garden Guesthouse

My cozy & stylish Garden Guesthouse features colorful decor that gives a fun, relaxed vibe. Relax in style inside or outside in my peaceful garden w a cup of coffee, or glass of wine. I love to say a hi to my guests yet your privacy is #1. Reach me via Airbnb app if I can help! Kensington is a central, 1920’s historic neighborhood w shops & great local eateries. Close to downtown, Gaslamp, Zoo, airport, beaches, Balboa Park. Bus stop, & trolley nearby. Reserved off street parking space too!

Sep. 13 – 20

$237 CAD per night

Guest favourite

Guesthouse in San Diego

4.93 out of 5 average rating, 447 reviews

Private Cottage in Walkable North Park w/AC

Welcome to our charming private Airbnb in vibrant North Park! Enjoy the perfect blend of comfort and convenience for your San Diego stay. Walk to restaurants, coffee shops, art galleries, wine bars, breweries, yoga studios & various boutiques. Nature lovers will adore the nearby Balboa Park with its stunning gardens and cultural attractions. Downtown, Gaslamp Quarter, beaches, and the famous San Diego Zoo are easily accessible. Book and create lasting memories in this dynamic neighborhood.

Jun. 21 – 28

$219 CAD per night

Guest favourite

Guesthouse in San Diego

4.93 out of 5 average rating, 356 reviews

Cozy Ocean Beach Casita

This cozy, clean casita is just 4 blocks to the beach, pier, great surfing, restaurants, bars, shopping, and Sunset Cliffs. You’ll love it for its walkability to everything you need. The casita is only 120 square feet, a very small space (small studio with everything in one room including the bathroom), for single occupancy only, but with everything you need to enjoy a San Diego getaway. It is great for solo travelers who want to be near the heart of Ocean Beach, San Diego, California.

Sep. 3 – 10

$171 CAD per night

Guest favourite

Guesthouse in San Diego

4.97 out of 5 average rating, 283 reviews

Betty- Guesthouse near CBX & San Ysidro border

This comfy studio located in San Diego is the perfect spot for a quiet & cozy weekend retreat. Inside is bright & inviting with stylish spacious studio, private entrance from side gate, private patio with bbq & hanging hammocks; driveway parking spot & plenty of street parking! The view from the patio is very relaxing, making it the perfect weekend get away. Centrally located in a quiet & peaceful area within 5 minutes away from Plaza Las Americas & 10 minutes away from the CBX.

Jan. 18 – 25

$195 CAD per night

Guest favourite

Guesthouse in San Diego

4.98 out of 5 average rating, 185 reviews

North Park Garden Retreat Casita

Nestled between the urban neighborhoods of North and South Park, our sanctuary within the heart of the city is surrounded by a secret garden that gives the impression of a tropical oasis. The private casita is tucked in the backyard of the Host’s home and has french doors which open to the lush greenery of the garden. Whether vacationing, traveling for work, or looking for an ideal space for relaxation and renewal, this is the perfect place to enjoy your San Diego stay.

Sep. 4 – 11

$176 CAD per night

Superhost

Guesthouse in La Jolla

4.82 out of 5 average rating, 425 reviews

Stunning studio in the heart of La Jolla

The studio has been totally refurnished and includes a King size bed, fridge/freezer, microwave, loveseat and all the amenities for a very enjoyable stay. A beautiful private studio with a spacious patio, ideally located within mins to the cosmopolitan La Jolla Village, restaurants, coffee shops, boutique stores, La Jolla cove, La Jolla Shores beach, Vons grocery store and so much more. The studio is at the rear of the main house which is also rented.

Mar. 26 – Apr. 2

$221 CAD per night

Guest favourite

Guesthouse in San Diego

4.91 out of 5 average rating, 413 reviews

Mission Hills Charming suite, walkable to all.

Heart of Mission Hills, upscale area, this private guest suite, separate from the house, is perched above the pool (separate building from main house), own entrance; sure to provide privacy. We are minutes from airport, walking distance to coffee & restaurants and central to all of SD. Please note this property is wiped down after each visit with Clorox as well as all linens washed. We also don’t rent back to back giving time for thorough cleaning.

Oct. 23 – 28

$175 CAD per night

Guest favourite

Guesthouse in San Diego

4.97 out of 5 average rating, 183 reviews

Fresh, hip and cozy private North Park guest house

Enjoy peaceful sunny San Diego days listening to the palm trees sway in this private backyard garden retreat set behind a 1925 California craftsman. The guest house is tucked away in a quiet quintessential Southern California neighborhood while only being a short and easy walk to amazing restaurants, world class breweries and cozy coffee shops. Balboa Park, the San Diego Zoo, beaches and downtown are all a few minutes drive away.

Jan. 17 – 24

$217 CAD per night

Guest favourite

Guesthouse in San Diego

4.97 out of 5 average rating, 190 reviews

California Cottage in North Park

Walking along side the main house into this secluded cottage, you’ll embark on your own vacay just 10 minutes from the airport. This converted separated garage is a home away from home with walking distance to University Ave with Communal Coffee for breakfast, and outdoor dinner dinning at Louisiana Purchase. If the zoo is what you desire, it is not a far walk but a little hike through the canyon is required.

Sep. 3 – 10

$215 CAD per night

Guest favourite

Guesthouse in San Diego

4.9 out of 5 average rating, 945 reviews

Safe Hip Quiet GARDEN STUDIO / Northpark

Come to a quiet and stylish studio for social distancing. Check in contactless and enjoy! Cozy, hip and private garden studio with private entrance, private full bathroom and private deck. Studio house is in a large garden adjoining a craftsman-style house in the historic Northpark/ Morley Field District. Minutes away from coffee shops, breweries, Zoo, Balboa Park.

Dec. 13 – 20

$197 CAD per night