Vacation rentals in Cape Girardeau

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Cape Girardeau

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favourite

Home in Cobden

4.93 out of 5 average rating, 54 reviews

Wine trail, views, hot tub, pool…

Escape your worries in this spacious, serene retreat. Whether your exploring the local wineries, embarking on a girl’s trips, hiking scenic trails, enjoying a family vacation, or even casting a line on a fishing trip, our home is the perfect destination. After a day of adventure, unwind in the comfort of our well-appointed space. End your day by the pool, soak in the hot tub, or enjoy a campfire. Located just a short distance from Bald Knob Cross. Cameras actively recording at all times.

Guest favourite

Cabin in Alto Pass

4.99 out of 5 average rating, 259 reviews

Ma's Cabin, Alto Pass, IL. Fine country lodging.

Cute and country remodel done in 2019. Recent new appliances, furnishings, flooring, heat & A/C, washer & dryer. Cabin is secluded and quiet plus 1/2 mile from Alto Pass Lookout Point and right in the middle of many award-winning wineries. 15 miles from Carbondale 4 miles from Giant City 30 miles from Garden of the Gods 6 lakes within 10-mile radius Hundreds of miles of hiking trails in nearby Shawnee National Forest 6 miles from Bald Knob Cross Please, no dogs! No smoking in cabin!

Superhost

Loft in Cape Girardeau

4.92 out of 5 average rating, 105 reviews

Riverwalk Loft 1

If you are looking for something right in the middle of the excitement, book now! This is your place. Our lofts are right in the heart of Downtown. In walking distance to breweries, casinos, and shopping galore.Our building is directly in front of the Mississippi River entrance. Walk around the corner either to get an ice cream for a late night snack. Beds are super comfortable but downtown isn’t the quiet part of town. The train runs periodically. You will have the typical night life noise.

Guest favourite

Cottage in Carbondale

4.84 out of 5 average rating, 70 reviews

Carbondale country home: Portas Caeli, 3

Relax in this gorgeous country setting minutes from SIU and eateries, close to hiking, and wine trails. Stroll around the property and catch glimpses of deer, maybe even a fox or coyote. The area is best described as peaceful and convenient. Spacious master suite on main floor has king size bed. Upstairs is a cozy converted loft with one private room with full size bed and one open loft bedroom with two twin beds. We even have a poured concrete walk-in tornado shelter off master suite.

Superhost

Home in Alto Pass

4.7 out of 5 average rating, 23 reviews

Notting Hill Cottage

Welcome! We are new to Airbnb but not to a sister site where we have a couple hundred 5star reviews. We have had our home as a rental for almost 5 years now! It has two bedrooms with one queen and two twin beds. A loft and a futon! A full kitchen. One bathroom with a tub/shower combo. You’ll find yourself relaxing on our large deck that spans the rear of the house. Sit in the hot tub overlooking the fenced-in yard and the woodlands below. Private wooded setting! Dogs welcome with fee.

Guest favourite

Apartment in Cape Girardeau

4.98 out of 5 average rating, 126 reviews

Downtown Penthouse w/ Amazing River View!

AMAZING RIVERVIEW Plus Close to Downtown Cape? Our Airbnb is the best place to be! Relax in our Roof Deck after going around downtown and ENJOY THE VIEW. Located in a safe and quiet neighborhood plus it is WALKING DISTANCE from everything! It features a roof deck with (by far) the best view in Cape, enough space for six to sleep (two queen beds and two couches), one off street parking spot and a building with secure entry. Plus we just live across the street if you need anything.

Superhost

Home in Carbondale

4.76 out of 5 average rating, 134 reviews

Brick Estate with pool in Quiet Neighborhood

Large fully furnished 4 BR, 3 BTH house in a beautiful, quiet neighborhood in Carbondale. Private pool & large backyard. Very safe & walkable neighborhood. Inspected and licensed by the City of Carbondale. Carbondale Vacation Rental Unit License Number 24-06. Basement with bar, pool table, ping pong. Complete kitchen with all utensils & cookware. Garden patio w/ Weber grill, tables, chairs, beautiful landscaping, etc. ***Pool is open from Memorial Day through Labor Day***

Guest favourite

Cabin in Cobden

4.88 out of 5 average rating, 168 reviews

Private, home away from home with lots of extras

Come enjoy your stay at our comfortable 4 bedroom lodge. The lodge has 3 large private bedrooms, each with a queen bed, the 4th bedroom has 2 twin beds. The lodge has a maximum occupancy of 8 people with 2 full bathrooms. The lodge is perfect for a family vacation, reunions and couples. 2 TVs with satellite, and a DVD on 1 TV (bring your favorite movies). A hot tub, gas grill, fire pit, fishing pond (bring your own fishing equipment) and an open lounging deck is available.

Guest favourite

Home in Alto Pass

4.99 out of 5 average rating, 115 reviews

The Farmhouse in Rhine Valley

Newly renovated Farmhouse in Alto Pass situated between Trail of Tears State Forest and just a hike or short drive away from Bald Knob Cross and wilderness. Minutes away from local wineries. Enjoy a peaceful pause from the hustle and bustle in our private little Farmhouse. Perfect for single family or small groups. Nearby venues and activities include: hiking, fishing, public hunting, wineries, restaurants, and many other local venues and events. Hunters are welcome.

Guest favourite

Cottage in Ava

4.94 out of 5 average rating, 101 reviews

Crazy Joe's Cabin #1

We have 3 great rentals. Crazy Joe’s Cabin # 2 and Hickey House on Airbnb. Located 2 miles off rt. 151 in Shawnee National forest. The cabin is along tree line just west of Crazy Joe’s Fish House. Restaurant is open at 4pm Wednesday, Friday and Saturday 1bedroom cabin with queen bed, living room with queen sleeper sofa. Full kitchen, bathroom with shower,washer/dryer. Great place for hunting or fishing trip or get away. Smart tvs you can access apps

Guest favourite

Home in Cobden

5 out of 5 average rating, 15 reviews

Domaine de Champagne

A menities, B eauty, C alm, D aydreaming, E uphoria, F un, G iant City State Park, H iking, I forgot, J ust because, K inship....POOL... SOUTHERN ILLINOIS...WINE TRAIL... YOU fill in the rest.... 2 Secluded acres just for you! Master Suite...Wow, Pool, Cooks Kitchen, Wrap Around Deck, Indoor/Outdoor Living. Everything you want. Honestly, it's just a wonderful place to be, your own oasis. No Passport needed. Pool is closed for season 10/1/24- 4/15/25

Guest favourite

Guest suite in Cape Girardeau

4.92 out of 5 average rating, 111 reviews

Downtown loft, walk to all the action, charming

This rental is in the heart of downtown Cape with all the restaurants, nightlife and shopping at your leisure. It is an airy upper unit on the corner of Themis and Spanish streets just one block from the mighty Mississippi. The owner's law office is housed on the main level. Included is king size bed, queen pull out couch, full size futon, and queen air mattress. Come and relax on the spacious deck and enjoy the local flair.